Contract Research Organization · Binghamton, NY

Translational science for the molecules others won't take on.

Xchem is an incorporated, PhD-led CRO uniting custom synthesis, regulated bioanalysis, and biocomputational modeling — supporting small-molecule, oligonucleotide, and bioconjugate programs from exploratory chemistry through the clinic.

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Founded 2021 · Incorporated PhD-led team of scientists & engineers
From the catalogue

Featured compounds

A rotating selection from our specialty reagents — linkers, phosphoramidites, biotin reagents, and reference standards.

Browse the full catalogue
Who we are

Senior expertise, delivered as a service.

Xchem provides niche translational-science services to pharmaceutical and biotech developers across exploratory, preclinical, and clinical stages. We combine specialized synthetic chemistry, regulated bioanalytical development, and computational modeling under one roof — letting small and mid-sized innovators access senior scientific expertise without carrying it in-house.

Core competencies

Six service areas across the discovery-to-regulatory continuum.

Custom & Complex Synthesis

Oligonucleotide phosphoramidites, bioconjugation & ADC linkers, and reference standards.

Bioanalytical & Analytical Methods

LC-MS/MS, HPLC, immunoassay, and ddPCR method development.

Analytical Method Validation

ICH Q2/Q3-aligned validation and transfer-ready methods.

Extractables & Leachables

Risk-based E&L aligned to ISO 10993 for FDA/EMA and 510(k) submissions.

Reference Standard Qualification

Synthesis, purification, and characterization with Certificates of Analysis.

Biocomputational Modeling

Virtual screening, molecular dynamics, and free-energy scoring.

Why partner with Xchem

What a lean, senior-led CRO brings to specialized programs.

Senior scientists engaged directly

Work is led by experienced PhD scientists across our disciplines — not handed down to junior staff.

Integrated across disciplines

Synthesis, bioanalysis, and computation coordinated by one accountable partner.

Regulatory-fluent by default

Methods and documentation built to ICH / ISO expectations and ready for transfer.

Agile & cost-effective

Niche, low-overhead capacity for the specialized work larger CROs deprioritize.

Get in touch

Let's advance your program.

Tell us where a program is stuck — a difficult synthesis, a method that won't validate, or chemistry you want triaged before the bench. We'll scope it.